Targeting tumor resistance mechanisms

Targeting Drug Resistance Mechanisms in Mycobacterium tuberculosis

Historically, tuberculosis (TB) has left a scar as mankind’s greatest infectious killer. With evidence of TB infection dating back nine millenia to a Neolithic Eastern Mediterranean settlement [1], this ancient disease meant almost certain death to those infected, a phenomenon spanning pre-antibiotic eras from the time of the Roman empire all the way to the beginning of the 20th century. But wi...

Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance.

Oxaliplatin was the first platinum drug with proven activity against colorectal tumors, becoming a standard in the management of this malignancy. It is also considered for the treatment of pancreatic and gastric cancers. However, a major reason for treatment failure still is the existence of tumor intrinsic or acquired resistance. Consequently, it is important to understand the molecular mechan...

Complement Resistance Mechanisms of Human Tumor Cells

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Targeting Mechanisms of Resistance to Taxane-Based Chemotherapy

Targeting tumor metastases: Drug delivery mechanisms and technologies.

Primary sites of tumor are the focal triggers of cancers, yet it is the subsequent metastasis events that cause the majority of the morbidity and mortality. Metastatic tumor cells exhibit a phenotype that differs from that of the parent cells, as they represent a resistant, invasive subpopulation of the original tumor, may have acquired additional genetic or epigenetic alterations under exposur...